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KMID : 1134820080370070826
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 7 p.826 ~ p.833
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Growth-inhibitory Effect of the Extract of Porphyran- Chungkookjang on Cancer Cell
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Min Hyun-Kyeng
Chang Hae-Choon
Kim Hyo-Ju
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Abstract
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The effects of porphyran-chungkookjang on cytotoxicity of human normal cell line (BJ) and human cancer cell lines (AGS and HT-29) were examined. Porphyran, which was prepared from laver (Porphyra yezoensis), decreased the viability of the cancer cells, however, it did not affect the viability of normal cells. Porphyranchungkookjang was prepared by the addition of 5% (w/w) porphyran into chungkookjang which was fermented by starter, Bacillus subtilis DJI. The cytotoxicity effects of the chungkookjang and porphyran-chungkookjang were evaluated with MTT assay. The methanol and the water extract of porphyran-chungkookjang at 1.0 mg/mL showed 23～38% decreases in proliferation of cancer cells (AGS and HT-29). However, the methanol and the water extracts of porphyran-chungkookjang did not inhibit the growth of normal cell. Moreover, the methanol extract of porphryan-chungkookjang at 1.0 mg/mL showed 1.2～1.5 fold higher anticancer effects than that of the chungkookjang.
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KEYWORD
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laver, porphyran, chungkookjang, anticancereffect
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